CortAlign contains a unique variety of botanicals and nutrients shown to have a blunting effect on stress and anxiety, as well as normalizing cortisol secretion. Ashwagandha has a number of adaptogenic effects, including modulating GABA receptors, which is partly responsible for the significant reduction in anxiety and stress as shown in clinical trials. The KSM-66
formulation of ashwagandha specifically has been shown to reduce serum cortisol levels by 27%, and improve markers of depression, stress, and anxiety compared to placebo.
The combination of magnolia and phellodendron (Relora
blend) helps reduce stress and anxiety, and has been shown to reduce salivary cortisol levels and perception of stress, improve other mood parameters, and prevent stress-related weight gain compared to placebo. L-theanine has also been shown to reduce anxiety in clinical trials, as well as both subjective stress and cortisol production in response to a stressful event.Phosphatidylserine plays a critical role in neuronal cell structure and function, and has been shown to blunt the stress response, improve mood, and normalize cortisol release.
Allergens:
Contains no artificial colours, preservatives, or sweeteners; no sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, salt, tree nuts, or GMOs. Suitable for vegetarians. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
Contraindications
Do not use if you are pregnant or breastfeeding.
Drug Interactions
L-theanine is known to have a hypotensive effect in some individuals, and concomitant use of CortAlign with anti hypertensive drugs may potentiate their activity. Theoretically, the herbs present in CortAlign may have additive effects when used with sedative medications, such as benzodiazepines or CNS depressants, and should be used with caution when taken concomitantly.
References
1. Candelario, M., Cuellar, E., Reyes-Ruiz, J.M., et al. (2015). Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAA and GABAρ receptors. J Ethnopharmacol, 171, 264-72.
2. Pratte, M.A., Nanavati, K.B., Young, V., et al. (2014). An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). J Altern Complement Med, 20(12), 901-8.
3. Chandrasekhar, K., Kapoor, J., Anishetty, S. (2012). A prospective, randomized doubleblind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med, 34(3), 255-62.
4. Talbott, S.M., Talbott, J.A., Pugh, M. (2013). Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr, 10(1), 37.
5. Garrison, R., Chambliss, W.G. (2006). Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med, 12(1), 50-4.
6. Ritsner, M.S., Miodownik, C., Ratner, Y., et al. (2011). L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study. J Clin Psychiatry, 72(1), 34-42.
7. White, D.J., de Klerk, S., Woods, W., et al. (2016). Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial. Nutrients, 8(1).
8. Benton, D., Donohoe, R.T., Sillance, B., et al. (2001). The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Nutr Neurosci, 4(3), 169-78.
9. Hellhammer, J., Vogt, D., Franz, N., et al. (2014). A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitaryadrenal- axis in chronically stressed male subjects: a randomized, placebo-controlled study. Lipids Health Dis, 13, 121.